Abstract

GIUGNO, Hilda et al. Early antibiotic treatment for eradication of initial infection by Pseudomonas aeruginosa in patients with cystic fibrosis. Arch. argent. pediatr. [online]. 2010, vol.108, n.2, pp.141-147. ISSN 0325-0075.

Introduction. Cystic fibrosis is a genetic autosomal recessive disease that affects approximately 1:6000 live births in our country. Chronic infection with Pseudomonas aeruginosa (PA) is associated with higher morbidity and-mortality, and deterioration of lung function. Treatment of initial infection is important to prevent or delay chronic infection. The primary aim was to determine the effectiveness and freetime of PA in bronchial secretions after eradication treatment. The secondary objective was to determine changes in the weight and lung function. Materials and methods. Prospective, observational study, of patients with cystic fibrosis (CF) and recent PA infection. After initial infection by PA patients received oral ciprofoxacin and nebulized colistin. We studied effectiveness of treatment to eradicate PA, and changes in the weight measured in Z score and in the respiratory functional tests, pre-infection, during, and after the eradication of PA. Results. We included 24 patients (11 male) with confirmed CF. Seven of them had two PA infections, and received 2 treatment courses. PA was eradicated in 24 (80.5%) out of 31 infections. The value of weight measured in Z score, and functional tests measures through the FVC and FEV1 decreased during the infection by PA, returning to the baseline after eradication. The free-time of PA during the follow-up to these patients was 23.75 (95% CI 14.38-32.86) months. Conclusion. Treatment of initial infection by PA has a high degree of response. Weight and functional values improved after treatment.

Keywords : Cystic fibrosis; Pseudomonas aeruginosa; Eradication treatment; Initial infections.

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