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Archivos argentinos de pediatría

Print version ISSN 0325-0075


MALLA, Ivone et al. Fulminant hepatic failure due to tuberculostatic drugs: Case report. Arch. argent. pediatr. [online]. 2012, vol.110, n.3, pp.e35-e38. ISSN 0325-0075.

Hepatoxicity of isoniazid, mainly in association with rifampin, is a rare secondary effect of tuberculostatic treatment. In the United States, it accounts for 0.2% of all pediatric orthotropic liver transplant, and 14% of transplants for drug hepatotoxicity. We report the case of a 10 year-old patient who presented with acute liver failure requiring orthotropic liver transplant after forty days of tuberculostatic treatment with isoniazid, rifampin and pyrazinamide.

Keywords : Antitubercular agents; Isoniazid; Acute liver failure; Liver transplantation.

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