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Archivos argentinos de pediatría
Print version ISSN 0325-0075
Abstract
BALINOTTI, Juan Emilio; COLOM, Alejandro; KOFMAN, Carlos and TEPER, Alejandro. Association between the Asthma Predictive Index and levels of exhaled nitric oxide in infants ans toddlers with recurrent wheezing. Arch. argent. pediatr. [online]. 2013, vol.111, n.3, pp.191-195. ISSN 0325-0075. http://dx.doi.org/10.5546/aap.2013.191.
It is difficult to make an early identification of which children with recurrent wheezing will develop asthma in the following years. The Asthma Predictive Index (API) is a questionnaire based on clinical and laboratory parameters used for this end. The measurement of fractional exhaled nitric oxide (FENO) has been used as a marker of eosinophilic airway infammation in asthma patients. Objective. To determine the association between the Asthma Predictive Index and FENO levels in children younger than 3 years old with recurrent wheezing. Materials and methods. Observational, cross sectional study. Children younger than 36 months old with 3 or more episodes of bronchial obstruction in the past year who were inhaled corticosteroid-naive or leukotriene receptor antagonist-naive were included. After recording clinical data, FENO was measured by a chemiluminescence analyzer during tidal breathing (online method). Results. A total of 52 children aged 5-36 months old were included. Patients with a positive API accounted for 60% of the population and had higher levels of FENO than those with a negative API, with a median (range) of 13.5 ppb (0.7-31) versus 5.6 ppb (0.1-20.8), respectively (p <0.01). A high FENO (>8 ppb) was observed in 74% of children with a positive API and in 26% of those with a negative API (p <0.01). Conclusions. This study found an association between high levels of exhaled nitric oxide and a positive Asthma Predictive Index in children younger than 3 years old with recurrent wheezing.
Keywords : Asthma predictive algorithm; Exhaled nitric oxide; Recurrent wheezing; Infants and toddlers.
