Abstract

PEREZ, Guadalupe M et al. Invasive infections caused by Streptococcus pneumoniae in a terciary care pediatric hospital before the introduction of the conjugate vaccine: Clinical characteristics and serotypes involved. Arch. argent. pediatr. [online]. 2013, vol.111, n.3, pp.202-205. ISSN 0325-0075.  http://dx.doi.org/10.5546/aap.2013.202.

Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1^st , 2008 and September 30^th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9% (n: 73) were OVER 2 years old and 89% (n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5%, n: 25), 6 (14.4%, n: 16), 19 (8.1%, n: 9), 23 (7.2%, n: 8), 1 (6.3%, n: 7), 5 (4.5%, n: 5), and 7 (7.2%, n: 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.

Keywords : Pneumococcal disease; Streptococcus pneumoniae; Pneumococcal serotypes; Pneumonia; Bacteremia.

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