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Archivos argentinos de pediatría

Print version ISSN 0325-0075


SIERRA-AVENDANO, Jairo Alonso; GARCIA-PINO, Ricardo  and  PEREZ-GARCIA, Gabriel Eduardo. A twelve-years-old girl with multiloculated gynandroblastoma CD99 negative: case report. Arch. argent. pediatr. [online]. 2014, vol.112, n.4, pp.e142-e146. ISSN 0325-0075.

The ginandroblastoma is an extremely rare ovarian tumor which shows components of granulosa cells and Sertoli/Leydig cells. We describe a case of a twelve-years-old girl who presented abnormal uterine bleeding and progressively growing intraabdominal mass associated with menorrhagia, CA-125 60.4 UI/mL and extension studies reporting cystic mass in the left ovary. She underwent oophorectomy. Pathological study shows a multilocular tumor filled with serous material. Many Call-Exner bodies were observed in the histopathological analysis, 45% of Sertoli/Leydig cells. Immunohistochemistry was reactive for inhibin, calretinin and pCK while AE1/AE3 and CD99 markers were negative. This is the first case report about a multiloculated gynandroblastoma, negative for CD99 in a 12-years-old girl. Thus, the study of this clinical case represents a systematic approach for tumors of the sex cord cells.

Keywords : Sex cord-gonadal stromal tumors; Gynandroblastoma; Children; Immunohistochemistry; Human CD99 antigen.

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