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Archivos argentinos de pediatría

Print version ISSN 0325-0075On-line version ISSN 1668-3501

Abstract

MANRIQUE, Belén; LOPEZ MARTI, Jessica; CACCIAVILLANO, Walter  and  ROSSI, Jorge. Multi-parametric Flow Cytometry for Neuroblastoma, a new and possible diagnostic tool: Case report. Arch. argent. pediatr. [online]. 2016, vol.114, n.2, pp.2-3. ISSN 0325-0075.  http://dx.doi.org/10.5546/aap.2016.e100.

Neuroblastoma is the most frequent extracranial solid tumor in childhood, representing 5.6% according to the "Registro Oncopediátrico Hospitalario Argentino". For its diagnosis, several complementary methods (radiological, biological and biochemical) are required, and Multi-parametric Flow Cytometry (MFC) arises as a potential diagnostic method, despite not having been so far extensively explored. MFC is a method that allows to obtain several information about size, internal complexity and antigenic expression by the use of a laser and fluorescent monoclonal antibodies. There is an increasing number of reports in the literature which reveal the importance of using MFC for diagnosis and monitoring of solid tumors. The aim in this presentation is to highlight the fundamental role that MFC had in the case of a patient affected by neuroblastoma, in whom an early diagnosis using this methodology allowed prompt administration of adequate treatment.

Keywords : Neuroblastoma; Flow cytometry; Non-Hematopoietic neoplasms; Children; Neoplasms.

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