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Archivos argentinos de pediatría

Print version ISSN 0325-0075On-line version ISSN 1668-3501


MARTINEZ FACI, Cristina et al. Azathioprine-induced pancytopenia: Case series. Arch. argent. pediatr. [online]. 2016, vol.114, n.4, pp.e252-e255. ISSN 0325-0075.

Azathioprine is an immunosuppressive drug that has shown effectiveness in inflammatory bowel disease treatment. Its metabolite, 6-mercaptopurine, is metabolized through thiopurine methyltransferase. Patients with low enzyme activity may have more frequent and severe side effects. The most common is leukopenia, and rarely pancytopenia. The thiopurine methyltransferase activity monitoring shows an individualized profile of enzymatic activity but it should not replace monitoring by performing serial blood counts. In patients with fever and severe neutropenia, early empirical antibiotic treatment should be initiated to prevent severe and disseminated infection. Two patients with this condition are reported.

Keywords : Azathioprine; Toxicity; Pancytopenia.

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