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Archivos argentinos de pediatría

Print version ISSN 0325-0075On-line version ISSN 1668-3501


CIOCCA, Mirta  and  ALVAREZ, Fernando. Neonatal acute liver failure: a diagnosis challenge. Arch. argent. pediatr. [online]. 2017, vol.115, n.2, pp.175-180. ISSN 0325-0075.

Neonatal acute liver failure is a rare, very severe disease with a high rate of mortality. It is clinically and etiologically different from acute liver failure seen in older children and adults. Coagulopathy with an international normalized ratio > 3 is the critical parameter that defines it. The most common causes are fetal alloimmune hepatitis, previously called neonatal hemochromatosis, viral infections, metabolic disorders, and hemophagocytic lymphohistiocytosis. There is a group of treatable diseases that require a very early diagnosis for the prescription of an adequate treatment. Patients should be immediately referred to a specialized facility where pediatric liver transplantation is available to implement such therapeutic alternative, if indicated.

Keywords : Neonatal liver failure; Congenital alloimmune hepatitis; Metabolic disorders; Liver transplantation.

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