Abstract

MARIN, Gustavo R; BASPINEIRO, Berta  and  VILCA, Iris. Treatment with sublingual desmopressin in two infants with hydranencephaly and central diabetes insipidus. Arch. argent. pediatr. [online]. 2018, vol.116, n.1, pp.e1-e7. ISSN 0325-0075.  http://dx.doi.org/10.5546/aap.2018.e93.

Central diabetes insipidus is a rare disease in children caused by a deficiency of vasopressin. Its main clinical manifestations are polyuria and polydipsia. Brain malformations are one of the main causes. Desmopressin is the synthetic drug of choice for the treatment. One of the routes of administration is sublingual and its use in infants is very limited. We describe two infants with central diabetes insipidus and hydranencephaly who were successfully treated with sublingual desmopressin.

Keywords : Central diabetesinsipidus; Desmopressin; Hydranencephaly; Nervous system malformations.

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