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Archivos argentinos de pediatría

Print version ISSN 0325-0075On-line version ISSN 1668-3501


AKıNCı, Burcu et al. Stevens-Johnson Syndrome associated with methotrexate treatment for acute lymphoblastic leukemia: a case report. Arch. argent. pediatr. [online]. 2018, vol.116, n.3, pp.e459-e462. ISSN 0325-0075.

Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare mucocutaneous diseases which are associated with a prolonged course and potentially lethal outcome. They are mostly drug induced and mortality rates are very high. Although mostly skin is involved, multiple organ systems such as cardiovascular, pulmonary, gastrointestinal, and urinary systems may be affected. Here, we report a case of StevensJohnson Syndrome associated with methotrexate treatment who developed acute cardiac failure and gastrointestinal hemorrhage beside skin findings. He had been treated with intravenous immunglobulin and methylprednisolone succesfully and continued chemotherapy with methotrexate treatment again.

Keywords : Stevens-Johnson syndrome; Toxic epidermal necrolysis; Methotrexate; Leukemia; Child.

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