Introduction

Mean plate let volume-to-lymphocyte ratio (MPVLR) has emergedas a novel parameter of inflammation andthrombosis. The aim was to evaluate whether MPVLR has a role in the diagnosis of childhoodappendicitis.

Population and methods

Retrospectively reviewed the medical records up to 18 yearwith suspected acute appendicitis (AA) who underwent appendectomy between January 2016 and December 2017. Based onhistopathological evaluation, the patients wereclassified into normal appendix, and simpleand perforated appendicitis. Preoperative meanplatelet volume (MPV), platelet distributionwidth (PDW), MPVLR, platelet-to-lymphocyteratio (PLR), counts of platelets and white bloodcells (WBC), and C-reactive protein (CRP) levelswere measured.

Results

A total of 219 children with clinically suspected AA who underwent surgical treatmentfor appendicitis were reviewed, and 100 gender-age matched healthy subjects were included. Compared with the controls, the mean levels of MPVLR, PLR, WBC and CRP were significantlyhigher in the children underwent appendectomy (p <0.001). These values were significantly higherin simple appendicitis than in normal appendices (p<0.01). Compared with simple appendicitis, these levels were significantly higher in thechildren with perforated appendicitis (p <0.001). The area under curves for MPVLR and PLR were 0.771 and 0.726 in the prediction of appendicitis and 0.693 and 0.722 in the prediction ofperforation, respectively.

Conclusions

Increased level of MPVLR may be valuable for aiding the diagnosis of pediatric AA. In addition, it can help discriminatesimple and perforated appendicitis in children.

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