SciELO - Scientific Electronic Library Online

 
vol.38 número2Detección de anticuerpos para Chagas y Toxoplasmosis en trasudado mucoso oralUtilidad de la ferritina sérica para evaluar depósitos de hierro maternos en el post parto inmediato índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Bookmark


Acta bioquímica clínica latinoamericana

versión On-line ISSN 1851-6114

Resumen

ENRIORI, Pablo J.; VICO, Clelia M.  y  ENRIORI, Carlos L.. Dilemma of obesity in both sexes. Acta bioquím. clín. latinoam. [online]. 2004, vol.38, n.2, pp. 165-171. ISSN 1851-6114.

In the gluteo-femoral obesity, the metabolic consequences are comparative scarce and the endocrine effects are directly linked to the excess of adipose tissue. In abdominal obesity the endocrine effects are very important: insulin resistance and hyperinsulinemia, increase of IGF-I activity, increase of active androgen production by ovarian estroma, important reduction of sex-hormone-binding-globulin (SHBG) and increasing "bioavailable" estradiol (E2), testosterone (T) and dihidrotestosterone (DHT). In short, obesity and abnormal endocrinology appear to be associated with the development of endometrium and breast cancer in women. Growth hormone (GH) secretion is markedly reduced in obesity, and hypothalamic, pituitary and peripheral factors may contribute to the abnormal GH secretion. GH plays a critical rol in the regulation of body composition and energy balance. The circulating leptin is a product of specific adipocyte ob-gene that exerts stimulating effect on GH release. Furthermore, selected series of obese patients have shown that high free insulin like growth factor (IGF-I) and low IGF-binding proteins generally increased in overweight subjects. Obesity is also characterized by fasting hyperinsulinemia and exaggerated insulin release after a glucose load. Recently it has also demonstrated that leptine plays an important role in the reproductive system at all levels of the hypothalamus-pituitary-gonadal axis.

Palabras llave : Obesity.; Hyperinsulinemia; Androgens; Estrogens.; Insulin-like growth factors.; Binding proteins.; Growth hormone; Leptine.

        · resumen en Español     · texto en Español     · pdf en Español