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Acta bioquímica clínica latinoamericana

versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114


DUBOSCQ, Cristina  y  KORDICH, Lucía. Effect of sodium citrate concentration on coagulation assays. Acta bioquím. clín. latinoam. [online]. 2005, vol.39, n.1, pp.87-92. ISSN 0325-2957.

The aim of this study was to assess the extent of influence of citrate concentration on the results of routine coagulation assays (prothrombin time (PT) and activated partial thromboplastin time (APTT). PT was evaluated using three tromboplastins of different origin and APTT was determined by four different APTT reagents. Three methods of clot detecction were used (manual, photo-optic and electromecanic).Three groups were studied: healthy volunteers, outpatients receiving stable dosis of oral anticoagulant therapy and hospitalized patients receiving non fractionated heparin therapy. There were no statistically significant differences of TP expressed in percentaje. In patients receiving dicumarinic therapy, the INR (International Normatized Ratio) obtained with two thromboplastins of lower ISI showed a statistically significant difference between two citrate concentrations. This difference is more important when the RIN is greater than 3.5. Effects of sodium citrate concentration on APTT were satistically significant in all groups when a reagent sensitive to aid the detection of lupus anticoagulant was used. For APTT the greatest change was observed in patients receiving heparin therapy.

Palabras clave : Sodium citrate concentration; Prothrombin time; Activated partial thromboplastin time.

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