Abstract

GUBER, Rosa Silvina; ARIAS DE SANDOVAL, Nilda; RUIZ DE MARTINEZ, Norma  and  SORIA DE GONZALEZ, Analía Graciela. Reference values for tumor serum markers dosed by immunoassay. Acta bioquím. clín. latinoam. [online]. 2005, vol.39, n.3, pp.315-322. ISSN 0325-2957.

The aim of this work was to determine the reference values (RV) for five tumor markers of great usefulness in oncologic medicine. The stated values were compared to the ones recommended by the manufacturers and the influence of the menstrual state over them was also studied. The levels of CA 15.3, CA 125, ferritin (Ferr), carcinoembryonic antigen (CEA) and prolactin (PRL) were determined in the serum of 335 healthy women (aged 15 to 65 years old). The RV based on percentile 95 were as follows: CA 15.3 = 20 U/mL; CA 125 = 24 U/mL; CEA = 3 ng/mL; PRL = 25 ng/mL, in premenopausic women. In healthy postmenopausic donors the RV were as follows: CA 15.3 = 24 U/mL; CA 125 = 19 U/mL; CEA = 4 ng/mL; PRL = 19 ng/mL. The RV of Ferr were as follows: 138 ng/mL, 171 ng/mL, 286 ng/mL for women donors less than 40 years old, 41-50 and over 51 years old, respectively. The observed reference values were not concordant with those recommended by the manufacturers, suggesting the importance of women's age or menopausal stage in serum marker levels.

Keywords : reference values; tumor marker; CA 15.3; CA 125; carcinoembryonic antigen; ferritin; prolactin; menopausic.

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