SciELO - Scientific Electronic Library Online

 
vol.40 número1Toxocara canis en caninos.: Prevalencia en la ciudad de La PlataConsecuencias del tipo de actividad laboral sobre algunos indicadores bioquímicos de riesgo aterogénico.: Estudio en población geriátrica del nordeste argentino índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

Compartir


Acta bioquímica clínica latinoamericana

versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114

Resumen

MARTINEZ SARRASAGUE, María et al. Current concepts on glutahione metabolism: Usefulness of stable isotopes of its homeostasis. Acta bioquím. clín. latinoam. [online]. 2006, vol.40, n.1, pp.45-54. ISSN 0325-2957.

Glutathione (GSH) plays an important role against free radicals, its blood concentration showing a strong correlation with in vivo oxidative stress. GSH concentration decreases with aging, strong fitness and oxidative stress among other pathologies like diabetes, cystic fibrosis, AIDS, cirrhosis, infections, protein malnutrition and chemotherapy treatments. The GSH performance in different physiological functions and diverse pathologies can be studied using labeled molecules with stable isotopes, for instance using 13C. The kinetic of the 13CO2, generated from a 13C-substrate, constitutes a useful tool for the studies of metabolic routes. The carboxilato 13C-oxatiazolidina (OTC) enables the evaluation of the glutathione balance in different pathological and physiological conditions, determining the redox state in each situation. In this work, different basic aspects of glutathione metabolism are discussed, as well as its relationship with different pathologies. The usefulness of stable isotopes is also analyzed as a non invasive tool for determining glutathione balance in human beings.

Palabras clave : glutathione; metabolism; oxidative stress; pathologies; stable isotopes; 13C-oxothiazolidine carboxylate.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons