Acta bioquímica clínica latinoamericana
versión On-line ISSN 1851-6114
GAMBA, Cecilia et al. Argentina's Public Cord Blood Bank: Beginning of the Unrelated Program. Acta bioquím. clín. latinoam. [online]. 2006, vol.40, n.4, pp. 491-497. ISSN 1851-6114.
The umbilical cord blood (UCB) is a rich source of hematopoietic progenitor cells (HPC). The Unrelated Program has been recently established and it has received financial support by the Ministry of Health to acquire new equipment. This Program was aimed at collecting and preserving UCB from altruistic donors. The units are potentially used for allogeneic bone marrow transplantation in those patients who lack a suitable compatible donor. From August 2005 to January 2006 110 donors have been enrolled and 96 units collected. Units processed (n=70) yield a mean recovery of 76.4 ± 7.4% of the total nucleated cell (TNC) collected with a final count of 0.8 ± 0.3 x 109 TNC and 2.79 ± 2.57 x 106 CD34+ cells per unit. By HLA analysis, those variants common in the Argentine population (A68, B3519, DR08) along with the less frequently found alleles were detected. This Program will make it possible to increase the availability of units from Hispanic-Latin American background that are scarce in registries from other countries.
Palabras clave : cord blood bank; hematopoietic progenitor cells; Unrelated Program.