Abstract

SCANDIZZO, Hilda Emilia  and  BERNSTEIN, Judith Celina. Detection of anti-R7V antibodies in patiens infected with the human immunodeficiency virus. Acta bioquím. clín. latinoam. [online]. 2009, vol.43, n.1, pp.37-42. ISSN 0325-2957.

The Human Immunodeficiency Virus incorporates cellular antigens to its viral surface during the budding process, among them b₂-microglobulin which is part of the Major Histocompatibility Complex Class I. The R7V epitope derived from b₂ microglobulin is present on the virion surface and is able to induce the formation of neutralizing antibodies against R7V, whose presence is associated with non-progression of the illness. ELISA test was Acta Bioquímica Clínica Latinoamericana performed for testing of samples from our population of HIV-positive patients during the June- 2006 to June-2007 period, and the following results were obtained: 5 (41 %) of 12 non-progressor patients, asymptomatic for a period of 5 years average (range 2-13 years) were positive for anti-R7V; 2 (14%) of 14 progressor patients receiving hightly activity antiretroviral therapy (HAART) were positive for anti-R7V. A difference was observed between the results of the two groups but it was not statistically different (OR 4.29; 0.49-53.36; p=0.11) to establish a concordance between non-progression of the disease and the presence of anti-R7V antibodies. The correlation between non progression and the presence of anti-R7V will be proved, as larger numbers of patients are tested, which represents a challenge for the development of new therapies.

Keywords : Anti-R7V antibodies; Non-progressor patients; ELISA test.

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