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Acta bioquímica clínica latinoamericana
versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114
Resumen
SCANDIZZO, Hilda Emilia y BERNSTEIN, Judith Celina. Detection of anti-R7V antibodies in patiens infected with the human immunodeficiency virus. Acta bioquím. clín. latinoam. [online]. 2009, vol.43, n.1, pp.37-42. ISSN 0325-2957.
The Human Immunodeficiency Virus incorporates cellular antigens to its viral surface during the budding process, among them b2-microglobulin which is part of the Major Histocompatibility Complex Class I. The R7V epitope derived from b2 microglobulin is present on the virion surface and is able to induce the formation of neutralizing antibodies against R7V, whose presence is associated with non-progression of the illness. ELISA test was Acta Bioquímica Clínica Latinoamericana performed for testing of samples from our population of HIV-positive patients during the June- 2006 to June-2007 period, and the following results were obtained: 5 (41 %) of 12 non-progressor patients, asymptomatic for a period of 5 years average (range 2-13 years) were positive for anti-R7V; 2 (14%) of 14 progressor patients receiving hightly activity antiretroviral therapy (HAART) were positive for anti-R7V. A difference was observed between the results of the two groups but it was not statistically different (OR 4.29; 0.49-53.36; p=0.11) to establish a concordance between non-progression of the disease and the presence of anti-R7V antibodies. The correlation between non progression and the presence of anti-R7V will be proved, as larger numbers of patients are tested, which represents a challenge for the development of new therapies.
Palabras clave : Anti-R7V antibodies; Non-progressor patients; ELISA test.