Acta bioquímica clínica latinoamericana
versión impresa ISSN 0325-2957
UTHRAPATHY, Subashini et al. Analgesic and anti-arthritic effect of Corallocarpus epigaeus. Acta bioquím. clín. latinoam. [online]. 2011, vol.45, n.4, pp. 739-756. ISSN 0325-2957.
Rheumatoid arthritis is a chronic inflammatory joint disease associated with the development of oxidative stress and inflammation. The safety and efficacy profile of 85% methanolic extract of Corallocarpus epigaeus (CE) was evaluated in the present study. In safety profile LD50 value was determined by carrying out an acute toxicity study. In efficacy profile, the analgesic activity was evaluated by both hot plate and tail immersion tests. The anti-inflammatory activity was assessed by carrageenan-induced paw edema and anti-arthritic effect by complete Freund's adjuvant induced arthritis. Phytochemical screening of different CE extracts and quantitative analysis of both raw herb and 85% methanolic extract have been also carried out. The methanolic extract displayed analgesic activity by increasing the response time in both hot plate and tail immersion method. Extract exhibited 23,19% of anti-inflammatory activity and 33,59% of anti-arthritic effect in complete Freund's adjuvant induced paw edema. The CE extract increased the antioxidant level, along with a decrease of the oxidative stress developed by complete Freund's adjuvant induced arthritis. In conclusion, CE is a rich source of phytochemicals with analgesic, anti-inflammatory and antioxidant activities.
Palabras clave : Corallocarpus epigaeus; Analgesic; Anti-inflammatory and antioxidant properties; Hot plate; Tail immersion; Carrageenan; Complete Freund's adjuvant.