Resumo

UTHRAPATHY, Subashini et al. Analgesic and anti-arthritic effect of Corallocarpus epigaeus. Acta bioquím. clín. latinoam. [online]. 2011, vol.45, n.4, pp.739-756. ISSN 0325-2957.

Rheumatoid arthritis is a chronic inflammatory joint disease associated with the development of oxidative stress and inflammation. The safety and efficacy profile of 85% methanolic extract of Corallocarpus epigaeus (CE) was evaluated in the present study. In safety profile LD₅₀ value was determined by carrying out an acute toxicity study. In efficacy profile, the analgesic activity was evaluated by both hot plate and tail immersion tests. The anti-inflammatory activity was assessed by carrageenan-induced paw edema and anti-arthritic effect by complete Freund's adjuvant induced arthritis. Phytochemical screening of different CE extracts and quantitative analysis of both raw herb and 85% methanolic extract have been also carried out. The methanolic extract displayed analgesic activity by increasing the response time in both hot plate and tail immersion method. Extract exhibited 23,19% of anti-inflammatory activity and 33,59% of anti-arthritic effect in complete Freund's adjuvant induced paw edema. The CE extract increased the antioxidant level, along with a decrease of the oxidative stress developed by complete Freund's adjuvant induced arthritis. In conclusion, CE is a rich source of phytochemicals with analgesic, anti-inflammatory and antioxidant activities.

Palavras-chave : Corallocarpus epigaeus; Analgesic; Anti-inflammatory and antioxidant properties; Hot plate; Tail immersion; Carrageenan; Complete Freund's adjuvant.

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