Abstract

POLO, Mónica et al. Antiproliferative and anticholesterogenic activityof statins and monoterpenes. Acta bioquím. clín. latinoam. [online]. 2013, vol.47, n.2, pp.343-351. ISSN 0325-2957.

Statins are competitive inhibitors of HMG-CoA reductase used in hypercholesterolemic patients. Monoterpenes are non-nutritive dietary components found in the essential oils of many plants with pharmacologic effects on mevalonate metabolism. The study is centered on the effects and action mechanisms of the monoterpene components of essential oils and the combination of monoterpenes between them and combined with simvastatin on cholesterogenesis, lipid metabolism and cellular proliferation in vitro using two established cell lines, Hep G2 (derived from a human hepatoblastoma), A549 (derived from a human lung adenocarcinoma) and in vivo in no host and host nude mice carrying implanted tumors derived from A549. This opens up great expectations about the potential of co-administration of different natural isoprenoids and essential oils in improving anti-cholesterolemic therapies and/or cancer treatment as well as in the potential synergism with statins as an alternative to lower effective doses, decreasing the likelihood of undesired and/or toxic effects.

Keywords : Mevalonte pathway; Statins; Monotepenes; Cellular proliferation; Cholesterogenesis; Hep G2 cells; A549 cells; Athymic mice.

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