Abstract

POMILIO, Alicia Beatriz; CIPRIAN OLLIVIER, Jorge Oscar  and  VITALE, Arturo Alberto. Lysyl oxidase (LOX) and LOX-like proteins: role of amino-oxidases, molecular and catalytic properties. Acta bioquím. clín. latinoam. [online]. 2013, vol.47, n.4, pp.639-644. ISSN 0325-2957.

Amino-oxidases belong to two groups of proteins: flavoenzymes and quinoenzymes. Lysyl oxidase (LOX) is a copper-containing quinoenzime, having lysyl-tyrosyl-quinone as cofactor. LOX levels are increased in many fibrotic diseases, and in some tumors promoting metastasis, while the enzyme expression is decreased in diseases that involve deterioration in copper metabolism. The role of LOX as amino oxidase in catalyzing the oxidative deamination of lysine residues in precursors of collagen and elastin is discussed, as well as the participation of other members of this gene family: LOXL1, LOXL2, LOXL3, and LOXL4, and their molecular properties. The biosynthesis, catalytic properties and reaction mechanism, cofactors and inhibitors, and the expression and response to various cellular effectors are analyzed.

Keywords : Lysyl oxidase; Quinoenzyme; Amino-oxidase; Lysyl-oxidase like 1 to 4: Catalytic properties; Cofactors and inhibitors; Action mechanism.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )