Abstract

SMALDINI, Paola Lorena; ORSINI DELGADO, María Lucía; FOSSATI, Carlos Alberto  and  DOCENA, Guillermo Horacio. New insights in immunotherapies for food allergies. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.1, pp.61-75. ISSN 0325-2957.

Allergic diseases are the most prevalent immunopathologies worldwide. Although different mechanisms -IgE-independent or IgE-dependent- can be involved in the immunopathogenesis, the latter are the most studied reactions since they can be life-threatening. Nowadays, allergen avoidance is the unique effective treatment for allergic patients. However, this is rather difficult to implement. For this reason, and based on the new insights into the mucosal immune system and the development of animal models of allergy, there is an increasing interest in developing novel therapies to control or reverse allergic disorders. Pre-clinical studies and clinical trials have been successful to prove that immunotherapies may accomplish mucosal mechanisms of allergen-specific tolerance, which are able to revoke the allergic sensitization. Since the main obstacle in these therapies still has adverse reactions induced during treatment, further studies are required to explore safe and effective therapeutic protocols. At this point, translational medicine is a flourishing field in the areas of basic science, applied science, and clinical research.

Keywords : Allergies; Immunoglobulin-E; Immunotherapy; Tolerance; Regulatory T cells; Mouse model.

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