Abstract

RIVADENEYRA, Leonardo; IVANI, Paola Carla; SCHATTNER, Mirta  and  POZNER, Roberto Gabriel. The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.2, pp.233-245. ISSN 0325-2957.

Perhaps for being considered mere megakaryocyte cytoplasmic debris responsible for wound repair alone, platelets have had a secondary role when compared to other cellular blood components. However, in the last 20 years we have learned much more about these fascinating cells, which have slowly regained a prominent place in hematology. This review discusses the most outstanding and novel contributions on platelet biogenesis, its regulation by the bone marrow microenvironment and humoral factors, analyzing from megakaryocyte generation to platelet release.

Keywords : Platelets; Megakaryocytes; Hematopoiesis; Megakaryopoiesis; Thrombopoiesis; Platelet biogenesis; Hemostasis; Thrombosis; Cytokines; Chemokines.

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