SciELO - Scientific Electronic Library Online

 
vol.50 número2Factor von Willebrand y Enfermedad de von Willebrand: nuevos enfoques diagnósticosRequerimientos de calidad en hemostasia: Variabilidad biológica versus estado actual de la metodología índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

Compartir


Acta bioquímica clínica latinoamericana

versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114

Resumen

REMOTTI, Lucía et al. Acquired inhibitors of blood coagulation: diagnostic perpective and especial cases. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.2, pp.291-301. ISSN 0325-2957.

Acquired inhibitors are rare disorders. They are associated with different clinical behaviours and significant morbi-mortality. Detection is important in order to start treatment urgently. There are either specific inhibitors, which  block function, against all coagulation factors, and VWF, or with interference effects, on one or more coagulation pathways. Specific inhibitors are either allo-antibodies developed in deficient patients, which give rise to therapeutic complication; or auto-antibodies, which are present in individuals without previous defects. There are specific antibodies that can affect clearance but which cannot block the function. Inhibitors with interference effects are immunoglobulins or other substances (heparin/heparinoids, FDP/fdp, PIVKAS, abnormal molecules, etc.) associated with different clinical settings (asymptomatic, bleeding, thrombosis and/or obstetric complications). Laboratory results are fundamental for the diagnosis. Global tests are able to detect the defect, which is not corrected by the addition of normal plasma; the type of inhibitor is then characterized and titration of the inhibitor is eventually performed. This is complex; there is variability in the results and there is likelihood of false positive or negative results; moreover, the tests are not strictly specific. Diagnostic algorithms are useful tools but they do not consider combined defects. It is a critical point to characterize the inhibitor and exclude possible interferences or concomitant defects; this demands application of the correct tests without misinterpretations.

Palabras clave : Acquired inhibitors of coagulation; Specific inhibitors; Inhibitors that interfere with coagulation factors; Coagulation tests; Coagulation factors.

        · resumen en Español | Portugués     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons