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Acta bioquímica clínica latinoamericana

Print version ISSN 0325-2957On-line version ISSN 1851-6114


MASTAGLIA, Silvina. Periostin expression in bone repair processes: sua expressão nos processos de reparação Óssea. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.3, pp.367-373. ISSN 0325-2957.

Periostin is a non-collagenous protein expressed mainly in the periosteum, which has an important role during embryonic bone formation but also when repairing bone lesions or metabolic bone diseases. In the first case, when healing fractures and during experimental animal models, a periostin increased expression has been observed immediately after fractures. These findings suggest that periostin may play an important role in periosteal callus formation during the early stage of fracture healing. In benign bone diseases, like fibrous dysplasia, the periostin over-expression was observed in the fibrous component lesion. So, this protein could be detected by immune histochemical technique in histopathology studies. Periostin is a soluble factor, which can be detected in peripheral blood. In recent years, several immunoassays have been developed, though the main limiting factor is the detection of all molecule circulating isoforms, without providing bone specificity. Development of new immunoassays with greater specificity and sensibility than the current ones is crucial to the research concerning the potential of periostin as a biomarker of periosteal metabolism, bone quality and resistance.

Keywords : Periostin; Periosteum; Bone lesion.

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