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Acta bioquímica clínica latinoamericana

Print version ISSN 0325-2957On-line version ISSN 1851-6114


ZENI, Susana Noemí. Bone and fat connection: obesity effect on bone health. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.3, pp.375-385. ISSN 0325-2957.

Osteoporosis and obesity are chronic disorders that are increasing in prevalence. The pathophysiology of these diseases is multifactorial and it includes genetic, environmental and hormonal determinants. Basic and clinical studies support an important interaction between adipose tissue and the skeleton similar to that found in osteoporosis and obesity. The belief that obesity is protective for bone has recently been revised. In fact, excess of fat mass might be a risk factor for osteoporosis and fragility fractures. Increasing evidence seems to indicate that different factors released by the fat tissue could play a key role in skeletal health. Adipokines, cytokines and free-fatty acids secreted by the obese fat mass can regulate bone remodelling decreasing bone formation and increasing bone resorption. Moreover they increase oxidative stress, increasing even more the negative effect on bone mass. This review considers literature data to understand bone-fat interactions and the clinical implications of linking obesity to osteoporosis.

Keywords : Bone; Bone remodelling; Adipocytes; Oxidative stress; Obesity; Osteoporosis.

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