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Acta bioquímica clínica latinoamericana

Print version ISSN 0325-2957On-line version ISSN 1851-6114


OLIVERI, Beatriz  and  ZENI, Susana. Hypovitaminosis D and Metabolic Syndrome development. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.3, pp.387-393. ISSN 0325-2957.

The metabolic syndrome (MS) is an heterophasic pathology, which in general terms, could be defined as the combination of risk factors associated with cardiovascular disease (CVD) and diabetes, characterized by insulin resistance, hypertension, high blood pressure, high levels of triglycerides (TGL) and abdominal obesity. Vitamin D deficiency may induce metabolic disturbances (hypertension, atherogeny, increased CVD, insulin-resistance, type II diabetes and central obesity), which favour the development of MS. The nutritional status for vitamin D could be evaluated by serum 25-hydroxyvitamin D levels (25OHD). Several studies have suggested the existence of an inverse relationship between 25OHD levels and the increased risk of SM. Central adiposity, insulin resistance and atherogeny are important risk factors for the development of SM. All of these factors are associated with vitamin D deficiency. Supplementation with vitamin D increases 25OHD levels and could reduce the risk of developing MS. To assess the long-term effects and the causal link between the nutritional status of vitamin D and the risk of developing MS it is necessary to perform prospective randomized, controlled, double-blind studies.

Keywords : Hypovitaminosis D; Metabolic Syndrome; Insulin-resistance; Obesity; Hypertriglyceridemia.

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