SciELO - Scientific Electronic Library Online

 
vol.51 número1Determinación de Levetiracetam en suero humano por cromatografía líquida con detección de arreglo de diodosComplejos inmunes IgM-ApoB100 modificadas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

Compartir


Acta bioquímica clínica latinoamericana

versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114

Resumen

GONZALEZ, Lucas et al. Immunoserology and molecular techniques for diagnosis of Chagas´ disease: rapid systematic review . Acta bioquím. clín. latinoam. [online]. 2017, vol.51, n.1, pp.63-74. ISSN 0325-2957.

In order to increase diagnostic accuracy, the World Health Organization recommends performing two or more immunoserological tests for the diagnosis of Chagas disease in chronic stage. The aim of this work was to make a rapid systematic review of the performance of immunoserological techniques and molecular methods in the general population. A total of 178 studies were identified, nine ofwhich were included. ELISA techniques showed the highest sensitivity (82-98%) and specificity (96-100%). Rapid methods presented values of sensitivity between 88-93% and 97-100% of specificity, while the molecular methods (PCR) showed highly variable levels of sensitivity (22-92%) and specificity (70-100%). These results indicate that ELISA techniques have adequate sensitivity and specificity. PCR, as well as rapid methods, showed great variability in the results, mainly due to the heterogeneity of the techniques and abundance of “in-house” methods.

Palabras clave : Chagas; Diagnosis; Sensitivity; Specificity; Polymerase chain reaction; Enzyme-linked immunosorbent assay ELISA; Indirect immunofluorescence; Indirect hemagglutination.

        · resumen en Español | Portugués     · texto en Español

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons