Abstract

FACIO, Maria Laura et al. The role of beta trace protein in different areas of Medicine. Acta bioquím. clín. latinoam. [online]. 2018, vol.52, n.4, pp.397-409. ISSN 0325-2957.

The beta trace protein (BTP), also called Prostaglandin D2 Synthase lipocalin type PGDS, is a glycoprotein between 23 and 29 kDa of low molecular weight that converts prostaglandin H2 in prostaglandin D2. BTP is a protein that has multiple clinical associations. Due to the characteristics of the molecule, it may indicate an early alteration in glomerular filtration; by the serum increase of its synthesis, it is a predictor of cardiovascular risk, and for its high concentration in cerebrospinal fluid (CSF), it is a marker of leakage. This protein can be measured in different biological fluids such as serum, urine, and CSF. The objective of this review is to update the knowledge about this protein as a biomarker. The significance of BTP in the field of biochemistry as a possible biomarker will depend on the patient's underlying pathology.

Keywords : Prostaglandin D2 synthase; Glomerular filtration; Cardiovascular risk; Cerebrospinal fluid leakage.

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