Resumen

LOPEZ, Graciela Ines  y  SCHREIER, Laura Ester. Armonizacion del estudio de lipidos en el laboratorio clinico. Acta bioquím. clín. latinoam. [online]. 2019, vol.53, n.4, pp.459-468. ISSN 0325-2957.

The health professionals who practice clinical biochemistry are aware of the lack of comparable results between laboratories, regardless of where and when they are performed. For many years, the objective of the quality management was the standardization of measurement procedures. The harmonization is beyond the methods and the analytical results, and it includes all the aspects to be taken into account during the whole process of the test. The clinical biochemistry laboratories have achieved important improvements in the quality of the analytical processes in the last decades, but greater effort is necessary for the vulnerability of the extra analytical procedures to ensure the comparison and the agreement of the results obtained by different clinical laboratories. The initiatives aimed to improve the harmonization of laboratory results have an ethical dimension and importance in the diagnosis of dyslipidemia associated with the development of atherosclerosis and the assessment of cardiovascular risk. The population studies still show difficulties in the identification of the best biomarker that can adequately show the cardiovascular risk in an individual. The correlation, discordance and concordance between biomarkers show that it is necessary to design a personalized laboratory test profile, and with standardized and harmonized markers that allow the prediction of risk.

Palabras clave : Lipids; Non-HDL cholesterol; Apolipoproteins; Lipoprotein (a); Harmonization; Standardization; Lipoproteins; Lipídios; Colesterol não HDL; Apolipoproteínas; Lipoproteína (a); Harmonização; Padronização.

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