Revista argentina de microbiología
versión On-line ISSN 1851-7617
VIGNOLI, R. et al. Genetic environment of CTX-M-2 in Klebsiella pneumoniae isolates from hospitalized patients in Uruguay. Rev. argent. microbiol. [online]. 2006, vol.38, n.2, pp. 84-88. ISSN 1851-7617.
We studied two CTX-M-2-producing Klebsiella pneumoniae clinical strains, K96005 and K13, isolated from hospitalized patients in Uruguay, during 1996 and 2003, respectively. The genomic surroundings of blaCTX-M-2 were characterized by PCR-mapping and DNA sequencing. Our results show that blaCTX-M-2 is included in a complex class-1 integron (InK13), associated with an orf513 in both isolates. The genetic array of the integron, aac(6')-Ib, blaCTX-M-2, orfD (gene cassette region), associated with an orf513-blaCTX-M-2, seems to be widely disseminated over the Río de la Plata region.
Palabras clave : orf513; class 1 integron; extended-spectrum b-lactamases; blaCTX-M-2.