Abstract

FACCONE, D.  and  RED WHONET et al. Fluoroquinolone-resistant Streptococcus agalactiae isolates from Argentina. Rev. argent. microbiol. [online]. 2010, vol.42, n.3, pp.203-207. ISSN 1851-7617.

Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005- 2007, WHONET - Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0,9%) of which proved to be resistant . Nine of them had come from 5 hospitals (in Buenos Aires City and 4 Argentinean provinces) and recovered from urine (n = 7) and vaginal screening cultures (n = 2). Three strains were also resistant to macrolides, lincosamides and B streptogramins due to the ermA gene. All nine fluoroquinolone-resistant isolates bore the same two mutations, Ser79Phe in ParC and Ser81Leu in GyrA proteins. Genetic relationships were analyzed by ApaI-PFGE and two clones were determined, A (n = 6) and B (n = 3). To our knowledge, these are the first fluoroquinolone-resistant S. agalactiae isolates detected in Latin America.

Keywords : Streptococcus agalactiae; Fluoroquinolone resistance; Argentina.

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