Abstract

INGOLD, Ana J et al. Detección del gen codificante de la metalo-ß-lactamasa VIM-2 en un integrón de clase 1 asociado con el gen bla_CTX-M-2 en un aislamiento clínico de Pseudomonas aeruginosa en el Uruguay: primera comunicación. Rev. argent. microbiol. [online]. 2011, vol.43, n.3, pp.198-202. ISSN 0325-7541.

VIM-2 metallo-ß-lactamase gen detection in a class 1 integron associated to bla_CTX-M-2 in a Pseudomonas aeruginosa clinical isolate in Uruguay: first communication. In order to analyze the presence of metallo-ß-lactamase in our country, we included in this study Pseudomonas aeruginosa isolates causing nosocomial infections in a hospital from Uruguay. The presence of a metallo-ß-lactamase VIM-2 in a class 1 integron and of an extended spectrum -lactamase CTX-M-2 was detected in one isolate. This is the first report of both genes, bla_CTX-M-2 and bla_VIM-2,in the same P. aeruginosa isolate. Although carbapenemases have been extensively documented in the world, this is the first report of an acquired metallo-ß-lactamase with carbapenemase activity in pathogenic bacteria in Uruguay.

Keywords : Integron; Carbapenemase; Pseudomonas; VIM-2; Metallo-ß-lactamase; CTX-M-2.

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