Abstract

FUENTES, G.; LARA, A.; PEON, E.  and  TORRES, M.. Preliminary evaluation of TEDMA/HEMA + HAP composites as bone substitutes and drug controlled delivery matrixes. Lat. Am. appl. res. [online]. 2005, vol.35, n.1, pp.9-14. ISSN 0327-0793.

Copolymeric composites of tetraethylenglycol dimethacrylate and 2-hydroxyethyl methacrylate with hydroxyapatite load were studied. It was demonstrated that doesn't exist a tendency to justify the behavior of the work and setting times of the studied materials cause probably by inhibitor absence. Similar values of enthalpy reactions were obtained for all the compositions according to the literature reports. A strong dependence of the composition exists in case of mechanical properties, diminishing the compression strength with the increase of the hydrofilicity. In a same way, the little swelling of the samples is demonstrated and therefore, the non participation of the diffusion like delivery mechanism. It was calculated the quantity of liberated drug which influences notably in the mechanical properties of the material and some parameters that suggest it mechanisms type dissolution-diffusion and/or migration to guide the drug delivery.

Keywords : Composites; Hydroxyapatite; Acrylic Monomers; Drug Delivery Systems; Mechanical Properties.

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