Abstract

MATKOVIC, S. R.; VALLE, G. M.  and  BRIAND, L. E.. Quantitative analysis of ibuprofen in pharmaceutical formulations through FTIR spectroscopy. Lat. Am. appl. res. [online]. 2005, vol.35, n.3, pp.189-195. ISSN 0327-0793.

The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablet form. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the infrared band corresponding to the carbonyl group centered at 1721.5 cm^-1. The specificity, linearity, detection limits, precision and accuracy of the calibration curve, ibuprofen extraction, infrared analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with the quantification of ibuprofen through UV detection. The recovery values obtained in the analysis of pharmaceuticals are within the 98-110 % range.

Keywords : Ibuprofen Quantification; FTIR Analysis; UV Analysis; Pharmaceuticals.

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