SciELO - Scientific Electronic Library Online

 
vol.41 issue2Identification of pale lager beers via image analysisMoisture migration during a tempering time after the heat treatment step in yerba maté processing author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Bookmark


Latin American applied research

Print version ISSN 0327-0793

Abstract

SONG, L.T.; JIANG, X.Y.; TANG, K.W.  and  MIAO, J. B.. Study on inclusion interaction of ibuprofen with Β-cyclodextrin derivatives. Lat. Am. appl. res. [online]. 2011, vol.41, n.2, pp. 147-151. ISSN 0327-0793.

The inclusion interaction of ibuprofen with hydroxypropyl-β-cyclodextrin (HP-β-CD), hydroxyethyl-β-cyclodextrin (HE-β-CD) and methyl-β-cyclodextrin (Me-β-CD) was investigated by fluorescence spectroscopy. Experimental conditions affecting the inclusion process, such as host molecule, HP-β-CD concentration and pH, were discussed in detail. The results suggested the formation of inclusion complexes with a stoichiometric ratio of 1:1 and HP-β-CD was more suitable to include neutral ibuprofen molecule. In addition, a phase solubility study was performed by mixing an excess amount of ibuprofen with aqueous solution containing increasing amount of β-CDs using UV-vis. The results indicated that the solubility of ibuprofen was increased by inclusion with β-CD derivatives, and HP-β-CD was most efficient among the three β-CD derivatives. Moreover, stable solid inclusion complexes were established and characterized by DSC.

Keywords : Ibuprofen; β-CD Derivatives; Inclusion Complex; Fluorescence Spectroscopy.

        · text in English     · pdf in English