SciELO - Scientific Electronic Library Online

vol.32 issue2Genotoxic effect of Physalis angulata L. (Solanaceae) extract on human lymphocytes treated in vitroChromosome comparison between populations of the collared peccary, Tayassu tajacu, raised in captivity author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links



Print version ISSN 0327-9545


HONG, Samin; PARK, Kyoungsoo; KIM, Chan Yun  and  SEONG, Gong Je. Agmatine inhibits hypoxia-induced TNF-a release from cultured retinal ganglion cells. Biocell [online]. 2008, vol.32, n.2, pp.201-205. ISSN 0327-9545.

The effect of hypoxia on the release of tumor necrosis factor-a (TNF-a) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-a in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-a and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-a production in RGCs. Agmatine significantly reduced TNF-a level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-a production of RGCs in hypoxic condition. These results demonstrate a possible neuroprotective mechanism for agmatine against hypoxic damage in RGCs.

Keywords : Retinal ganglion cell; Tumor necrosis factor-a; Hypoxia; Agmatine.

        · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License