Abstract

ZHOU, Liping; GUO, Xiaolin; BA, Jing  and  ZHAO, Lianshuang. CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity. Biocell [online]. 2010, vol.34, n.2, pp.91-94. ISSN 0327-9545.

CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes.  Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.

Keywords : Cell migration; Lamellipodia formation; Uropod formation; Hyaluronic acid.

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