Abstract

PRADOS, A. P et al. Meloxicam does not modify cefalexin disposition in dogs. InVet [online]. 2008, vol.10, n.1, pp.21-36. ISSN 1668-3498.

The purpose of the present study was to describe intravenous cephalexin pharmacokinetics in healthy dogs and to investigate if previous administration of meloxicam affects it. Seven Beagle dogs were included in this study. Each dog received intravenous 25 mg/kg cephalexin (experience 1) or cephalexin 5 minutes after intravenous 0.1 mg/kg meloxicam (experience 2), with a 2 week wash out period. Cephalexin plasma concentrations were determined by microbiological assay. No statistical differences were found in cephalexin pharmacokinetic parameters between experiences. Consequently, when meloxicam is co-administered intravenously with cephalexin it doesn’t modify the pharmacokinetic of the antibiotic.

Keywords : Cephalexin; Meloxicam; Interaction; Dogs.

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