Abstract

SOLANA, H et al. Immunolocalization of Tubulin in testis of fasciola hepatica exposed to triclabendazole "in vivo". InVet [online]. 2009, vol.11, n.2, pp.105-115. ISSN 1668-3498.

Fascioliosis, an important zoonotic disease produced by the trematode Fasciola hepatica, causes significant economic losses in ruminant species over the entire world (worldwide). Its control is largely based on the use of the triclabendazole, a benzimidazole flukicidal compound. The mechanism of action of benzimidazole anthelmintic compounds is based on its union to β tubulin with the consequent depolymerization of its microtubules causing the loss of function and the loosening and the death of the parasite. In the specific case of triclabendazole this mechanism not yet has been resolved completely. In the present work was evaluated the effect "in vivo" of triclabendazole on the distribution of α tyrosinated tubulin and β tubulin in the testis tubules of F. hepatica obtained from bovines exposed to this drug. The obtained results confirm that triclabendazole (TCBZ) alters the distribution of the microtubules and reaffirm that at least it is one of its main mechanisms of action.

Keywords : Fasciola hepatica; Triclabendazole; Tubulin.

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