SciELO - Scientific Electronic Library Online

 
vol.13 número1Garrapatas (Acari: Ixodidae) asociadas a perros en diferentes ambientes de la provincia de Corrientes, Argentina índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Bookmark


InVet

versión On-line ISSN 1668-3498

Resumen

ARENCIBIA, D.F.; ROSARIO, L.A; SUAREZ, Y.E  y  DELGADO, L. Spontaneous and induced frequency of transplacental micronucleus in Sprague Dawley rats. InVet [online]. 2011, vol.13, n.1, pp. 53-61. ISSN 1668-3498.

The aim of this work were to determine the spontaneous and induced frequency of transplacental micronucleis in Sprague Dawley rats, demonstrating the clastogenic or aneugenic effects in the fetus through the maternal exposure, and their linking with the genotoxic and reproductive effect. Four experimental groups were formed, 1) negative control (mockery), 2) solvent control NaCl (0,9 %), 3) cyclophosphamide to 50 mg/kg, and 4) bleomycin to 30 mg/kg. All the groups were administered the 14, 15 and 16 days of the gestation by intraperitoneal route. 48 h to the last inoculation was preceded to the euthanasia, being obtained the maternal bone marrow and fetal liver samples. Bigger induction of damage was observed in fetal hepatic cells when it was compared with maternal bone marrow cells. It was demonstrated that the cyclophosphamide is able to induce bigger citotoxicity and genotoxicity that the bleomycin in both cellular types, demonstrating the transplacental clastogenic potential of both mutagens linking this genotoxicity assay to the reproduction. These results are used in the new drugs evaluation with antigenotoxic effects by transplacental route.

Palabras llave : Transplacental micronucleus; Sprague Dawley rats; Genotoxicity; Pregnancy.

        · resumen en Español     · texto en Español     · pdf en Español