Abstract

WEYERS, A et al. Lipoperoxidation levels in rainbow trout and broiler chickens after levofloxacin administration. InVet [online]. 2011, vol.13, n.1, pp.93-98. ISSN 1668-3498.

Levofloxacin is a fluoroquinolone antimicrobial used in human medicine and with a potential application in food-producing animals, if the toxicological and pharmacological studies support this. Previous studies have shown that other fluoroquinolones and/or its metabolites produce lipid peroxidation in animal tissues but toxicological evaluation of levofloxacin communications are scarce. This work argues evaluate the possible lipid oxidation in broiler chickens and trout (Oncorhynchus mykiss) tissues, after levofloxacin administration, using the thiobarbituric acid reactive substances technique (TBARs). The values, TBARs/g of tissue, showed statistically significant differences in: trout muscle after a10mg/kg single administration of levofloxacin 50.2±3.2 vs control 17.1±3.8 (p<0.05) at 72 h; in chicken after a single 5mg/kg levofloxacin administration, the values were in muscle at 2 h, 6.2±1.2 vs control 3.7±1.3 (p<0.05) and in liver at 1h, 6.9±0.2 vs control 0.9±0.1 (p<0.05). This information which suggests oxidative effect induction in tissues should be deepened in future research.

Keywords : Levofloxacin; Oxidative stress; TBARs; Trout; Chickens.

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