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Revista veterinaria

versión On-line ISSN 1669-6840


RAMIREZ, G.V. et al. Disminución del desarrollo de cáncer experimental del colon en ratas alimentadas con leche de búfala. Rev. vet. [online]. 2012, vol.23, n.1, pp.15-19. ISSN 1669-6840.

Bovine milk contains elements with potential to inhibit carcinogenesis; in turn, buffalo milk is of a high value as it contains more total solids, fat, protein and lactose compared to the former. The objective of this study was to determine the anticancer effect of buffalo milk on the development of tumors and dysplastic crypt foci (DCF) in colon of rats treated with the carcinogen 1,2-dimethylhydrazine. Rats (n= 78) were randomly divided into lots that received water or milk, with and without treatment with the carcinogen, during 123 and 240 days. At the end of the experiment macro and microscopic analysis of the large intestine were performed on each animal, determining the presence, number and location of tumors and DCF. The results showed significant reduction in tumor number (60%) and DCF (62.5%) in lots that received milk compared to those that received water. These results allow us to demonstrate that buffalo milk reduces both the development of tumors and dysplastic lesions of colon carcinogenesis in an experimental model of the large intestine

Palabras clave : buffalo; milk; colon cancer; 1,2-dimethylhydrazine.

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