Revista argentina de neurocirugía
versión On-line ISSN 1850-1532
MEZZADRI, Juan José. Discectomía cervical anterior con o sin injerto: metanálisis de la evolución y fusión. Rev. argent. neurocir. [online]. 2009, vol.23, n.1, pp. 1-7. ISSN 1850-1532.
Objective: To determine if in adult patients (both sexes) with radiculopathy or mielopathy, caused by a cervical disc hernia (soft or hard), in 1-2 levels, anterior discectomy with grafting (ADG) improves clinical outcome and fusion postoperatively, compared with anterior discectomy without grafting (AD). Methods: After the bibliographic search (1958-2003), 5 randomized controlled trials allocating patients to ADG or AD were retrieved. The methodological quality was assessed by 2 observers using: internal validity, external validity, data presentation and statistical analysis. Postoperative outcome (PO) and presence of fusion (F) were compared. Overall treatment effect was calculated using a meta-analytic fixed effect model (Peto model) from the Cochrane Colaboration (RevMan -version 4.0). Results were expressed as odds ratio (95% CI). Heterogeneity was measured using standard chi square test. Sensitivity analysis was performed calculating the treatment effect with a meta-analytic randomized effect model. Results: Trial methodological quality comprised applicability. PO was compared in 5 trials (n:315): there was no statistically significant heterogeneity (chi square=3.15/p=0.53); OR=0.68 (95% CI 0.40-1.15). The presence of F was compared in 4 trials (n:221): there was no statistically significant heterogeneity (chi square=0.01/p=0.99); OR=13 (95% CI 4.05-41.70). Sensitivity analysis did not show differences. Conclusion: The results of this meta-analysis did not show evidences that grafting or not grafting improved PO, but did show evidences that grafting increased F.
Palabras clave : Anterior cervical discectomy; Cervical fusion; Discal hernia; Metanalysis; Postoperative outcome.