Revista argentina de neurocirugía
versión On-line ISSN 1850-1532
MOROCHO RIOFRIO, Pablo et al. Estesioneuroblastoma y panhipopituitarismo: presentación de un caso. Rev. argent. neurocir. [online]. 2010, vol.24, n.1, pp. 61-66. ISSN 1850-1532.
Objectives. To report a case of esthesioneuroblastoma associated to hypopituitarism as a late complication of its treatment, to review the literature regarding treatment and prognosis and to resent a guideline for the diagnosis of hypopituitarism in these patients. Description. A 68-year-old male patient presented with a submaxilar metastasis of a very large esthesioneuroblastoma that involved both ethmoidal bones and invaded left cribiform plate and frontal lobe. Intervention. The patient underwent combined modality treatment with preoperative radio and chemotherapy, and craniofacial sugery of the tumor. Twenty months later he was admitted with a seizure and severe hyponatremia. A diagnosis of panhypopituitarism was made, and his sodium reverted to normal with de administration of 10 mg of hydrocortisone p.o. Conclusions Esthesioneuroblastomas are rare tumours that require multimodality treatment with surgery, radiotherapy and chemotherapy. Hypopituitarism is a late and potentially fatal complication that must be suspected and tested during the patients' whole lifespan.
Palabras clave : Esthesioneuroblastoma; Olfactory neuroblastoma; Hypopituitarism; Octreotide; Craniofacial surgery; Hyponatremia.