SciELO - Scientific Electronic Library Online

 
vol.74 número3Disección espontánea de la arteria coronaria descendente anterior tratada mediante cirugía sin circulación extracorpórea índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Bookmark


Revista argentina de cardiología

versión On-line ISSN 1850-3748

Resumen

SUAREZ, Jorge E.  y  BRAVO, Alicia I.. Conexins and the Cardiovascular System. Rev. argent. cardiol. [online]. 2006, vol.74, n.3, pp. 149-156. ISSN 1850-3748.

Intercellular communication is an essential biologic event of multicellular organisms and is associated with cell growth and differentiation control, apoptosis, adaptive responses of differentiated cells and the synchronization of cellular functions. A kind of intercellular junctions known as gap junctions, actively participate in these processes and are structurally made of conexins. From a cardiovascular viewpoint, cell to cell communication, under normal conditions, is essential in cardiac embryogenesis, electrical impulse transmission, synchronization of cardiac contractile activity, transmission of vascular reflex signals and other biological functions. Under pathological conditions, either by inherited or acquired genetic mutation, intercellular communications participate in the development of congenital cardiopathies, arrhythmogenesis and electrical remodelling, atherosclerosis and myocardial ischemia, arterial hypertension and myocardial remodelling. Genetic and molecular research will probably find the means to prevent and treat the different cardiopathies where intercellular communication plays a physiopathological role.

Palabras llave : Arrhythmia; Connexins; Molecular biology; Congenital defects; Endothelium; Genetics; Myocardium.

        · resumen en Español     · texto en Español