SciELO - Scientific Electronic Library Online

 
vol.74 número4Detección de aneurisma de la aorta abdominal en una población derivada para ecocardiografía transtorácicaEl aumento del riesgo de mortalidad en la cirugía cardíaca: ¿Realmente estamos operando pacientes con incremento del riesgo? índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Bookmark


Revista argentina de cardiología

versión On-line ISSN 1850-3748

Resumen

D'ANNUNZIO, Verónica et al. Ischemic Postconditioning Reduces Infarct by Activating Adenosine Receptors in Animals with Normal and High Cholesterol Levels. Rev. argent. cardiol. [online]. 2006, vol.74, n.4, pp. 224-228. ISSN 1850-3748.

Ischemic postconditioning (Postcon) reduces infarct size in normal animals. However, since the effect of Postcon in hypercholesterolemic animals is unknown, our objective was to determine whether Postcon reduces infarct size in hypercholesterolemic animals. The second objective was to assess if A1 receptors are involved in protective Postcon mechanisms. Isolated isovolumic hearts of normal and hypercholesterolemic rabbits were perfused according to Langendorff's technique and subjected to 30 minutes of global ischemia and 30 min of reperfusion (G1). During G2, Postcon was elicited (two 30 second-cycles of reperfusion/ ischemia) after 30 min of ischemia. During G3, we repeated G2, but an A1 receptor blocker (DPCPX, 200 nM) was administered. During G4, G5 and G6, all these experimental protocols were repeated in animals fed with a cholesterolrich diet (1%) for 4 weeks. The following parameters were measured: pressure developed in the left ventricle (LVP), end-diastolic LV pressure (LVEDP), and infarct size assessed by triphenyl tetrazolium (TTC). The infarct size was 15.7±1.5% in G1 and 24.4±3.1% in G4. Postcon reduced the infarct area to 5.5±0.9% in normal animals and to 5.6±1.6% in hypercholesterolemic animals (p<0.05 vs. G1 and G4). When DPCPX was administered, the protective effect of Postcon was abolished in both groups of animals (G3, 15.1±1.7 and G6, 21.2±1.9). Hence, Postcon reduces infarct size in normal and hypercholesterolemic animals, through the activation of A1 receptors.

Palabras llave : Myocardial infarction; Ischemic postconditioning; Hypercholesterolemia.

        · resumen en Español     · texto en Español