Revista argentina de cardiología
versión On-line ISSN 1850-3748
The objective of cellular cardiomyoplasty is to regenerate the myocardium by implantation of living cells. However, in ischemic heart disease the extracellular myocardial matrix is modified; type I collagen (responsible for structural support) decreases from 80 to 40% while type III collagen increases from 10 to 35%. Therefore, it becomes important to associate the implanted cells to an extracellular bioartificial matrix. The purpose of this clinical study was to evaluate the performance of a biodegradable collagen matrix seeded with cells and grafted onto the left ventricular surface.
Palabras clave : Heart Failure; Congestive; Stem Cells; Tissue Engineering.