Revista argentina de cardiología
versión On-line ISSN 1850-3748
AVELLANA, Patricia et al. Severe Cardiac Complications of Chemotherapy: A Review. Rev. argent. cardiol. [online]. 2007, vol.75, n.1, pp. 55-60. ISSN 1850-3748.
In recent years, there has been an increase in the use of various pharmacological protocols for the treatment of oncological disorders, often with curative effects or a clear improvement in survival and quality of life. Some schemes include drugs that may cause severe cardiotoxic effects. Such effects prompt patients to consult the cardiologist, who generally has no previous experience in dealing with these complications. Hence, in this review, we summarize the mechanisms of action and adverse effects of various drugs that are frequently used in neoplastic diseases, and we also present clinical cases with serious adverse reactions, which complicate the decision-making process. Finally, we discuss several issues that need to be considered for the prevention, control and treatment of cardiotoxicity due to chemotherapeutic agents.
Palabras clave : Antracyclines; Fluorouracil; Gemcitabine; Cardiotoxicity.